OTT-MAL Is a Deregulated Activator of Serum Response Factor-Dependent Gene Expression
نویسندگان
چکیده
منابع مشابه
PKA-dependent phosphorylation of serum response factor inhibits smooth muscle-specific gene expression.
OBJECTIVE Our goal was to identify phosphorylation sites that regulate serum response factor (SRF) activity to gain a better understanding of the signaling mechanisms that regulate SRF's involvement in smooth muscle cell (SMC)-specific and early response gene expression. METHODS AND RESULTS By screening phosphorylation-deficient and mimetic mutations in SRF(-/-) embryonic stem cells, we ident...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2008
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.00303-08